Protonix

If you have a liver condition, make sure the doctor is aware of it. A dosage adjustment may be needed for anyone with serious liver disease.

Protonix has not been tested for safety or effectiveness in children.

Possible food and drug interactions when taking Protonix

If Protonix is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Protonix with the following:

• Ampicillin
• Iron
• Ketoconazole
• Warfarin

Special information if you are pregnant or breastfeeding

Although no harmful effects during pregnancy are known, there's no definite proof of safety either. Protonix is therefore recommended during pregnancy only if clearly needed. If you are pregnant or plan to become pregnant, inform your doctor immediately.

There is a possibility that Protonix may appear in breast milk, causing serious side effects in the nursing infant. If you have to take the drug, you should not plan on breastfeeding.

Recommended dosage for Protonix

ADULTS

Erosive Esophagitis

The usual dose is 40 milligrams once a day for up to 8 weeks. If your esophagus hasn't healed in that time, your doctor may prescribe an additional 8-week course of therapy. The same dose is used to maintain healing.

Overproduction of Stomach Acid

The usual starting dose is 40 milligrams twice a day. The doctor may increase the dose if necessary. Doses as high as 240 milligrams per day have been used. Treatment may continue for years.

Overdosage

Any medication taken in excess can have serious consequences. Although little is known about Protonix overdose in humans, in animal studies it interferes with coordination and reduces activity. If you suspect an overdose, seek medical attention immediately.