Sinequan

Possible food and drug interactions when taking Sinequan

Alcohol increases the danger in a Sinequan overdose. Do not drink alcohol while taking this medication.

Never combine Sinequan with drugs known as MAO inhibitors. Medications in this category include the antidepressants phenelzine and tranylcypromine.

If you are switching from fluoxetine, wait at least 5 weeks after your last dose of fluoxetine before starting Sinequan.

If Sinequan is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Sinequan with the following:

• Antidepressants that act on serotonin
• Other antidepressants such as amitriptyline nefazodone
• Carbamazepine
• Cimetidine
• Clonidine
• Flecainide
• Guanethidine
• Major tranquilizers
• Propafenone
• Quinidine
• Tolazamide

Special information if you are pregnant or breastfeeding

The effects of Sinequan during pregnancy have not been adequately studied. If you are pregnant or planning to become pregnant, inform your doctor immediately. Sinequan may appear in breast milk and could affect a nursing infant. If this medication is essential to your health, your doctor may advise you to discontinue breastfeeding your baby until your treatment is finished.

Recommended dosage for Sinequan

ADULTS

The starting dose for mild to moderate illness is usually 75 milligrams per day. This dose can be increased or decreased by your doctor according to individual need. The usual ideal dose ranges from 75 milligrams per day to 150 milligrams per day, although it can be as low as 25 to 50 milligrams per day. The total daily dose can be given once a day or divided into smaller doses. If you are taking this drug once a day, the recommended dose is 150 milligrams at bedtime.

The 150-milligram capsule strength is intended for long-term therapy only and is not recommended as a starting dose.

For more severe illness, gradually increased doses of up to 300 milligrams may be required as determined by your doctor.