Sporanox

Special warnings about Sporanox

In rare cases, Sporanox has been known to cause liver failure and even death, sometimes within the first week of treatment. Sporanox treatment is strongly discouraged if you have liver disease or have experienced liver toxicity from other drugs. If you take Sporanox continuously for more than a month, your doctor should monitor your liver function periodically. If you develop such symptoms of liver disease as unusual fatigue, loss of appetite, nausea, vomiting, jaundice, dark urine, or pale stool, stop taking Sporanox and contact your doctor immediately.

People with cardiac problems such as congestive heart failure should avoid Sporanox unless the benefit clearly outweighs the danger. In fact, anyone who is even at risk of heart failure should use Sporanox with caution. Risk factors include heart and lung disorders and kidney failure. If you experience swelling--especially in the feet and ankles--or difficulty breathing while taking Sporanox, stop taking this medication and contact your doctor immediately.

If you develop any nerve disorders while taking Sporanox, see your doctor. Treatment will probably need to be discontinued.

Possible food and drug interactions when taking Sporanox

If Sporanox is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Sporanox with any of the following:

Acid-blocking drugs such as Tagamet, Pepcid, and Zantac
Alprazolam (Xanax)
Atorvastatin (Lipitor)
Blood-thinning drugs such as Coumadin
Buspirone (BuSpar)
Busulfan (Myleran)
Caffeine-containing agents such as Cafergot
Calcium channel blockers such as Cardene, Norvasc, and Procardia
Carbamazepine (Tegretol)
Cilostazol (Pletal)
Clarithromycin (Biaxin)
Cyclosporine (Sandimmune, Neoral)
Diazepam (Valium)
Disopyramide (Norpace)
Dofetilide (Tikosyn)
Digoxin (Lanoxin)
Docetaxel (Taxotere)
Eletriptan (Relpax)
Erythromycin (E-Mycin, Ery-Tab, and others)
Indinavir (Crixivan)
Isoniazid
Levacetylmethadol
Lovastatin (Mevacor)
Methylprednisolone (Medrol)
Midazolam (Versed)
Nevirapine (Viramune)
Oral diabetes medications such as DiaBeta, Diabinese, Glucotrol, Micronase, Orinase, and Tolinase
Phenobarbital
Phenytoin (Dilantin)
Pimozide (Orap)
Quinidine (Quinidex)
Rifabutin (Mycobutin)
Rifampin (Rifadin, Rimactane)
Ritonavir (Norvir)
Saquinavir (Invirase)
Simvastatin (Zocor)
Sirolimus (Rapamune)
Tacrolimus (Prograf)
Triazolam (Halcion)
Trimetrexate (Neutrexin)
Vinblastine (Velban)