Tofranil

• The most common side effects in children being treated for bedwetting are:
  Nervousness, sleep disorders, stomach and intestinal problems, tiredness

• Other side effects in children are:
  Anxiety, collapse, constipation, convulsions, emotional instability, fainting

Why should Tofranil not be prescribed?

Tofranil should not be used if you are recovering from a recent heart attack.

People who take drugs known as MAO inhibitors, such as the antidepressants Nardil and Parnate, should not take Tofranil. You should not take Tofranil if you are sensitive or allergic to it.

Special warnings about Tofranil

In clinical studies, antidepressants increased the risk of suicidal thinking and behavior in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of Tofranil or any other antidepressant in a child or adolescent must balance this risk with the clinical need. Tofranil has not been studied in children less than 6 years old. Tofranil-PM is not approved for use in children.

Additionally, the progression of major depression is associated with a worsening of symptoms and/or the emergence of suicidal thinking or behavior in both adults and children, whether or not they are taking antidepressants. Individuals being treated with Tofranil and their caregivers should watch for any change in symptoms or any new symptoms that appear suddenly--especially agitation, anxiety, hostility, panic, restlessness, extreme hyperactivity, and suicidal thinking or behavior--and report them to the doctor immediately. Be especially observant at the beginning of treatment or whenever there is a change in dose.

You should use Tofranil cautiously if you have or have ever had: narrow-angle glaucoma (increased pressure in the eye); difficulty in urinating; heart, liver, kidney, or thyroid disease; or seizures. Also be cautious if you are taking thyroid medication.

General feelings of illness, headache, and nausea can result if you suddenly stop taking Tofranil. Follow your doctor's instructions closely when discontinuing Tofranil.