Tranxene

Special information if you are pregnant or breastfeeding

The effects of Tranxene during pregnancy have not been adequately studied. However, because there is an increased risk of birth defects associated with this class of drug, its use during pregnancy should be avoided. Tranxene may appear in breast milk and could affect a nursing infant. If this medication is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment with this medication is finished.

Recommended dosage

ANXIETY

Adults

The usual daily dosage is 30 milligrams divided into several smaller doses. A normal daily dose can be as little as 15 milligrams. Your doctor may increase the dosage gradually to as much as 60 milligrams, according to your individual needs.

Tranxene can also be taken in a single bedtime dose. The initial dose is 15 milligrams, but your doctor will adjust the dosage to suit your individual needs.

Tranxene-SD, a 22.5-milligram tablet, and Tranxene-SD Half Strength, an 11.25-milligram tablet, can be taken once every 24 hours. Your doctor may switch you to this form of the drug after you have been taking Tranxene for several weeks.

Older Adults

The usual starting dose is 7.5 to 15 milligrams per day.

ACUTE ALCOHOL WITHDRAWAL

Tranxene can be used in a multi-day program for relief of the symptoms of acute alcohol withdrawal.

Dosages are usually increased in the first 2 days from 30 to 90 milligrams and then reduced over the next 2 days to lower levels. After that, your doctor will gradually lower the dose still further, and will take you off the drug when you are ready.

WHEN USED WITH ANTIEPILEPTIC DRUGS

Tranxene can be used in conjunction with antiepileptic drugs. Follow the recommended dosages carefully to avoid drowsiness.

Adults and Children over 12 Years Old

The starting dose is 7.5 milligrams 3 times a day. Your doctor may increase the dosage by 7.5 milligrams per week to a maximum of 90 milligrams a day.

Children 9 to 12 Years Old

The starting dose is 7.5 milligrams twice a day. Your doctor may increase the dosage by 7.5 milligrams a week to a maximum of 60 milligrams a day.

Safety and effectiveness in children under 9 years of age have not been established.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical treatment immediately.

• Symptoms of Tranxene overdose may include:
  Coma, low blood pressure, sedation