Zerit

Another side effect seen in some people receiving drugs for HIV is a redistribution of body fat, leading to extra fat around the middle, a "buffalo hump" on the back, and wasting in the arms, legs, and face. Researchers don't know whether this represents a long-term health problem or not.

The benefit you get from Zerit may not last long. If your symptoms begin to get worse, tell your doctor immediately.

Possible food and drug interactions when taking Zerit

Combining Zerit with any of the following drugs may make peripheral neuropathy worse.

• Chloramphenicol
• Cisplatin
• Dapsone
• Didanosine
• Ethambutol
• Hydralazine
• Lithium
• Metronidazole
• Nitrofurantoin
• Phenytoin
• Vincristine
• Zalcitabine
• Zidovudine

Remember, too, that combination therapy with Zerit, didanosine, and hydroxyurea increases the possibility of serious liver problems. Combining Zerit and didanosine also increases the risk of pancreatitis.

Special information if you are pregnant or breastfeeding

The possibility that Zerit may harm a developing baby has not been ruled out. The drug should be used during pregnancy only if its benefits seem to outweigh the possible risk. The combination of Zerit and didanosine should be used with particular caution during pregnancy due to the danger of liver damage.

Do not breastfeed; HIV can be passed to a newborn infant through breast milk.

Recommended dosage for Zerit

ADULTS

For adults weighing 132 pounds or more, the usual dose is 40 milligrams every 12 hours. For those under 132 pounds, the dose is 30 milligrams every 12 hours.

CHILDREN

The usual starting dose for children weighing less than 66 pounds is 1 milligram per 2.2 pounds of body weight every 12 hours. Children weighing 66 pounds or more should take the adult dose.

Dosage is often reduced for people with kidney problems.

Overdosage

Numbness, pain, and tingling of the hands and feet can be signs of an overdose. If you suspect an overdose, seek medical attention immediately.