Zofran

Special warnings about Zofran

If drugs similar to Zofran (for instance, Anzemet or Kytril) have given you a reaction, Zofran may cause one too.

If you suffer from phenylketonuria (an excess of the amino acid phenylalanine) remember that Zofran contains this substance.

Possible food and drug interactions when taking Zofran

No interactions with Zofran have been reported.

Special information if you are pregnant or breastfeeding

The effects of Zofran during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Zofran may appear in breast milk and could affect a nursing infant. If this medication is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment with this medication is finished.

Recommended dosage

Dosage is the same for both regular and orally disintegrating tablets. If you have poor liver function, you should take no more than 8 milligrams of Zofran per day.

PREVENTION OF NAUSEA AND VOMITING DUE TO CHEMOTHERAPY

Adults and Children 12 Years of Age and Older

The recommended dose of Zofran is one 8-milligram tablet or 2 teaspoonfuls of oral solution taken twice a day. The first dose should be taken 30 minutes before the start of treatment. The other dose should be taken 8 hours after the first dose. One 8-milligram tablet or 2 teaspoonfuls should be taken twice a day (every 12 hours) for 1 to 2 days after completing chemotherapy.

If the chemotherapy is especially likely to cause nausea and vomiting, the recommended dosage is one 24-milligram tablet taken 30 minutes before the treatment.

Children 4 through 11 Years of Age

The recommended dose of Zofran is one 4-milligram tablet or 1 teaspoonful of oral solution taken 3 times a day. The first dose should be taken 30 minutes before the start of chemotherapy. The other 2 doses should be taken 4 and 8 hours after the first dose. One 4-milligram tablet or 1 teaspoonful should be taken 3 times a day (every 8 hours) for 1 to 2 days after completing chemotherapy.