Symbyax

Take the forgotten dose as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular schedule. Do not take two doses at once.

--Storage instructions...

Store at room temperature. Keep the container tightly closed and protect the drug from moisture.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe to continue using Symbyax.

• More common side effects may include:
  Abnormal thinking, increased appetite, lack of coordination, sleepiness, sore throat, tremor, water retention (especially in the arms and legs), weakness, weight gain

Why should Symbyax not be prescribed?

Symbyax is a combination of the ingredients in Prozac and Zyprexa. You cannot use Symbyax if you have experienced an allergic reaction to any of its ingredients, or to Prozac or Zyprexa. Make sure that your doctor is aware of any drug reaction that you have experienced.

Do not take Symbyax with an MAO inhibitor (see "Most important fact about this drug") or with thioridazine (Mellaril) (see "Possible food and drug interactions while taking this medication").

Special warnings about Symbyax

In clinical studies, antidepressants increased the risk of suicidal thinking and behavior in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of Symbyax or any other antidepressant in a child or adolescent must balance this risk with the clinical need. Symbyax is not approved for use in children.

Additionally, the progression of major depression is associated with a worsening of symptoms and/or the emergence of suicidal thinking or behavior in both adults and children, whether or not they are taking antidepressants. Individuals being treated with Symbyax and their caregivers should watch for any change in symptoms or any new symptoms that appear suddenly--especially agitation, anxiety, hostility, panic, restlessness, extreme hyperactivity, and suicidal thinking or behavior--and report them to the doctor immediately. Be especially observant at the beginning of treatment or whenever there is a change in dose.